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|  | Sanjai Kumar
Bioorganic & medicinal chemistry
Remsen, Room 117C
Phone: 718-997-4120
sanjai.kumar@qc.cuny.edu
Personal Home Page
Design, synthesis and evaluation of tight-binding inhibitors of clinically important enzyme targets using a combination of rational and combinatorial approaches, enzyme kinetics and molecular modeling. |  | |
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| | Glendon Dale McLachlan
Biochemistry
Remsen, Room 206D
Phone: 718-997-4185
glendon.mclachlan@qc.cuny.edu
Personal Home Page
The research in my lab investigates the relationship between the 3D structures of proteins and how a sampled conformation imparts function. High resolution NMR spectroscopy and spectroscopic methods such as CD, UV-Vis and Trp Fluorescence will be used to shed light on the structural perturbations of proteins in distinct solvents. We are investigating the conformational transitions and dynamics of spider silk proteins in conditions that mimetics the natural processing. | | |
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| | Susan A. Rotenberg
Biochemistry
Remsen, Room 117B
Phone: 718-997-4133
Susan.Rotenberg@qc.cuny.edu
Personal Home Page
Protein kinase C (PKC) is a Ca2+ and phospholipid-dependent protein kinase that is a vital component in various signaling pathways that govern proliferation, differentiation, and cell movement. In malignant cells, PKC promotes unregulated cellular growth and metastasis, as evidenced by 1) its role as the cellular receptor for tumor promoters, 2) its elevated levels of expression in certain tumors, and 3) disturbances in proliferation, migration, and reduction-oxidation processes of cells genetically engineered to overproduce PKC | | |
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| | Uri Samuni
Biophysics, Biochemistry, Physical Chemistry, Bio-nanotechnology, Biophotonics
Remsen, Room 26A
Phone: 718-997-4223
Uri.Samuni@qc.cuny.edu
Personal Home Page
Prof. Uri Samuni has a doctorate in Physical Chemistry from the Hebrew University of Jerusalem, Israel, and postdoctoral training at the Keck Biomolecular Laser Research Center, Albert Einstein College of Medicine. Our research is interdisciplinary in nature involving physical chemistry, biophysics, photonics and nanophotonics. The main objective of our research is combining spectroscopy, specifically, resonance Raman and surface enhanced Raman spectroscopy (SERS), sol-gel encapsulation of proteins and nanoparticles. In sol-gel encapsulation, proteins are embedded in the inert and optically transparent sol-gel matrix and yet remain functionally active. This constitutes a unique platform for the study of protein conformational dynamics and the characterization of non-equilibrium conformations as they relate to protein function. Moreover, depending on the preparative conditions, this novel photonic material lends itself to a large range of applications such as biosensors and sol-gel based nanoparticles and their biomedical applications. | | |
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Chair: Wilma Saffran
Dept. Office: Remsen 206
Phone: 718-997-4100, 4482 or 4191
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