Department of Psychology

Stress-Induced Analgesia

With the isolation of the opiate receptor and the discovery of the opioid peptides, an obvious question was the functional significance of this system, especially as it related to pain inhibition. Our laboratory, together with a number of others, found that acute exposure to environmental stressors produced a robust analgesic response, whereas chronic repeated exposure to environmental stressors produced adaptation to this same response in a manner similar to the time course of opiate analgesic tolerance. Subsequent findings indicated that certain stressors (or even specific parameters of the same stressor) produced analgesia mediated by the opioid system, whereas other stressors (or different parameters of the same stressor) produced analgesia independent of the opioid system. Similar patterns of analgesic responses identified stressors mediated by the pituitary gland, whereas others acted independently of this system. This led to the formulation of four different types of analgesic stressors: a) opioid-neural; b) opioid-neurohormonal; c) nonopioid-neural; and d) nonopioid-neurohormonal. Given the existence of different mechanisms of pain inhibition, a collateral inhibition hypothesis and been tested and demonstrated whereby activation of one pain-inhibitory system produces analgesia, yet reduces the activation of a second pain-inhibitory system, allowing for a hierarchical organization of activation of multiple pain-inhibitory systems.

Related Publications of the Bodnar Laboratory:

Hopkins, E, M Spinella, ZW Pavlovic and RJ Bodnar. Alterations in swim stress-induced antinociception following serotonergic or NMDA antagonists in the rostral ventromedial medulla of rats. Physiol. Behav.64: 219-225, 1998.

Pavlovic, ZW, ML Cooper and RJ Bodnar. Enhancements in swim stress-induced hypothermia, but not analgesia following amygdala lesions in rats. Physiol. Behav. 59: 77-82, 1996.

Spinella, M and RJ Bodnar. Nitric oxide synthase inhibition selectively potentiates swim stress analgesia in rats. Pharmacol. Biochem. Behav. 47: 727-733, 1994.

Pavlovic, Z and RJ Bodnar. Antinociceptive and hypothermic cross-tolerance between continuous and intermittent cold-water swims in rats. Physiol. Behav. 54: 1081-1084, 1993.

Robertson, JA and RJ Bodnar. Site-specific modulation of morphine and swim-induced antinoci-ception following thyrotropin-releasing hormone in the rat periaqueductal gray. Pain 55: 71-84, 1993.

Kelly, DD, A-J Silverman, M Glusman and RJ Bodnar. Characterization of pituitary mediation of stress-induced antinociception in rats. Physiol. Behav. 53: 769-775, 1993.

Bodnar, RJ Measurement of stress-induced analgesia. In: PM Conn (Ed), Methods in Neurosciences, Volume 14: Paradigms for the Study of Behavior, pp. 281-293, 1993.

Fisher, MC and RJ Bodnar. 2-deoxy-D-glucose antinociception and serotonin receptor subtype antagonists: test-specific effects. Pharmacol. Biochem. Behav. 43: 1241-1246, 1992.

Koch, JE, LB Hough and RJ Bodnar. Potentiation of 2-deoxy-D-glucose antinociception, but not hyperphagia by zolantidine, a histamine (H2) receptor antagonist. Pharmacol. Biochem. Behav. 41: 371-376, 1992.

Kest, B, M Orlowski and RJ Bodnar. Increases in opioid-mediated swim antinociception following endopeptidase 24.15 inhibition. Physiol. Behav. 50: 843-845, 1991.

Lubin, E, B Kest and RJ Bodnar. Differential actions of central alloxan upon opioid and nonopioid antinociception in rats: a further examination. Brain Res. Bull. 27: 35-39 1991.

Steinman, JL, PL Faris, PE Mann, JW Olney, BR Komisaruk, WD Willis and RJ Bodnar. Antagonism of morphine analgesia by nonopioid cold-water swim analgesia: direct evidence for collateral inhibition. Neurosci. Biobehav. Rev. 14: 1-7, 1990.

Bodnar, R.J. Effects of opioid peptides on peripheral stimulation and ‘stress’-induced analgesia in animals. CRC Crit. Rev. Neurobiol. 6: 39-49, 1990.

Lubin, E and RJ Bodnar. Differential actions of central alloxan upon opioid and nonopioid antinociception in rats. Pharmacol. Biochem. Behav. 34: 511-516, 1989.

Sathaye, N and RJ Bodnar. Dissociation of opioid and nonopioid analgesic responses following adult monosodium glutamate pretreatment. Physiol. Behav. 46: 217-222, 1989.

Kiefel, JM, D Paul and RJ Bodnar. Reduction in opioid and nonopioid forms of swim analgesia by 5-HT2 receptor antagonists. Brain Res. 500: 231-240, 1989.

Arjune, D and RJ Bodnar . Post-natal morphine differentially affects opiate and stress analgesia in adult rats. Psychopharmacol. 98: 512-517, 1989.

Robertson, JA, LB Hough and RJ Bodnar. Potentiation of opioid and nonopioid forms of swim analgesia by cimetidine. Pharmacol. Biochem. Behav. 31: 107-112, 1988.

Lubin, E and RJ Bodnar. Intracerebroventricular alloxan reduces 2-deoxy-D-glucose analgesia. Physiol. Behav. 42: 465-470, 1988.

Kepler, KL and RJ Bodnar. Yohimbine potentiates cold-water swim analgesia: re-evaluation of a noradrenergic role. Pharmacol. Biochem. Behav. 29: 83-88, 1988.

Yoburn, BC, LS Truesdell, B Kest, CR Inturrisi and RJ Bodnar. Chronic opioid antagonist treatment facilitates non-opioid stress-induced analgesia. Pharmacol. Biochem. Behav. 27: 525-527, 1987.

Truesdell, LS and RJ Bodnar. Reduction in cold-water swim analgesia following hypothalamic paraventricular nucleus lesions. Physiol. Behav. 39: 727-731, 1987.

Butler, PD and RJ Bodnar. Neuromodulatory effects of TRH upon swim and cholinergic analgesia. Peptides 8: 299-307, 1987.

Bodnar, RJ, M-T Romero, B Kest and EA Stone. Reduction in 2-deoxy-D-glucose analgesia following acute, but not chronic antidepressant treatment. Psychopharmacol. 91: 207-208, 1987.

Sperber, ES, E Kramer and RJ Bodnar. Effects of muscarinic receptor antagonism upon two forms of stress-induced analgesia. Pharmacol. Biochem. Behav. 25: 171-179, 1986.

Kramer, E and RJ Bodnar. Age-related decrements in the analgesic response to cold-water swims. Physiol. Behav. 36: 875-880, 1986.

Kramer, E and RJ Bodnar. Age-related decrements in stress-induced analgesia. Ann. N.Y. Acad. Sci. 467: 433-435, 1986.

Sperber, ES, TG Sperber and RJ Bodnar. Differential actions of scopolamine upon the analgesic responses to stress and pilocarpine. Ann. N.Y. Acad. Sci. 467: 436-438, 1986.

Butler, PD, PE Mann and RJ Bodnar. Comparison of central and peripheral thyrotropin releasing hormone (TRH) administration upon stress induced analgesia. Ann. N.Y. Acad. Sci. 467: 430-432, 1986.

Bodnar, RJ Neuropharmacological and neuroendocrine substrates of stress-induced analgesia. Ann. N.Y. Acad. Sci. 467: 345-360, 1986.

Kordower, JH and RJ Bodnar. Differential effects of dPTyr(me) AVP, a vasopressin antagonist, upon foot shock analgesia. Int. J. Neurosci. 28: 269-278, 1985.

Kramer, E, ES Sperber and RJ Bodnar. Age-related decrements in the analgesic and hyperphagic responses to 2-deoxy-D-glucose. Physiol. Behav. 35: 929-934, 1985.

Bodnar, RJ, PE Mann and EA Stone. Potentiation of cold-water swim analgesia by acute, but not chronic desipramine administration. Pharmacol. Biochem. Behav. 23: 749-752, 1985.

Butler, PD and RJ Bodnar . Potentiation of footshock analgesia by thyrotropin-releasing hormone. Peptides 5: 635-639, 1984.

Badillo-Martinez, D, N Nicotera, PD Butler, AL Kirchgessner and RJ Bodnar . Impairments in analgesic, hypothermic and glucoprivic stress responses following neonatal monosodium glutamate. Neuroendocrinol. 38: 438-446, 1984.

Bodnar, RJ and BR Komisaruk. Reduction in cervical probing analgesia by repeated exposure to cold-water swims. Physiol. Behav. 32: 653-655, 1984.

Bodnar, RJ Types of stress that induce analgesia. In: Stress-Induced Analgesia., MD Tricklebank, PH Huston, G Curzon (Eds) Wiley, 19-32, 1984.

Bodnar, RJ, E Kramer, DA Simone, AL Kirchgessner and J Scalisi. Dissociation of analgesic and hyperphagic responses following 2-deoxy-D-glucose. Int. J. Neurosci. 21: 225-236, 1983.

Simone, DA and * RJ Bodnar*. Tail-pinch hyperalgesia and analgesia: test-specific opioid and non-opioid actions. Learning Motiv. 14: 367-379, 1983.

Bodnar, RJ, KP Merrigan and E Sperber. Potentiation of cold-water swim analgesia and hypothermia by clonidine. Pharmacol. Biochem. Behav. 19: 447-451, 1983.

Bodnar, RJ and V Sikorszky. Naloxone and cold-water swim analgesia: parametric considerations and individual differences. Learning Motiv. 14: 223-237, 1983.

Bodnar, RJ, DA Simone, JH Kordower, AL Kirchgessner and G Nilaver. Capsaicin treatment and stress-induced analgesia. Pharmacol. Biochem. Behav. 18: 65-71, 1983.

Bodnar, RJ and E Sperber. Cold-water swim analgesia following pharmacological manipulation of GABA. Behav. Neural Biol. 36: 311-314, 1982.

Bodnar, RJ , NS Sharpless, JH Kordower, M Potegal and G Barr. Analgesic responses following adrenal demedullation and peripheral catecholamine depletion. Physiol. Behav. 29: 1105-1109, 1982. Kirchgessner, AL, RJ Bodnar and GW Pasternak. Naloxazone and pain-inhibitory systems: evidence for a collateral inhibition model. Pharmacol. Biochem. Behav. 17: 1175-1179, 1982.

Simone, DA and RJ Bodnar. Modulation of antinociceptive responses following tail pinch stress. Life Sci. 30: 719-729, 1982.

Bodnar, RJ, AL Kirchgessner, G Nilaver, J Mulhern and EA Zimmerman. Intraventricular capsaicin: alterations in analgesic responsivity without depletion of substance P. Neuroscience 7: 631-638, 1982.

Bodnar, RJ, JH Kordower, MM Wallace and H Tamir. Stress and morphine analgesia: alterations following p-chlorophenylalanine. Pharmacol. Biochem. Behav. 14: 645-651, 1981.

Bodnar, RJ, K Merrigan and MM Wallace. Analgesia following intraventricular administration of 2-deoxy-D-glucose. Pharmacol. Biochem. Behav. 14: 579-581, 1981.

Bodnar, RJ, M Lattner and MM Wallace. Antagonism of stress-induced analgesia by D-phenylalanine, an anti-enkephalinase. Pharmacol. Biochem. Behav. 13: 829-833, 1980.

Bodnar, RJ, EA Zimmerman, G Nilaver, A Mansour, LW Thomas, DD Kelly and M Glusman. Dissociation of cold-water swim and morphine analgesia in Brattleboro rats with diabetes insipidus. Life Sci. 26: 1581-1590, 1980.

Bodnar, RJ, DD Kelly, LW Thomas, A Mansour, M Brutus and M Glusman. Chlordiazepoxide antinociception: cross-tolerance with opiates and with stress. Psychopharmacol. 69: 107-110, 1980.

Bodnar, RJ, DD Kelly, LW Thomas and M Glusman. 2% saline treatment: failure to alter morphine and cold-water stress analgesia. Physiol. Behav. 24: 805-808, 1980.

Bodnar, RJ, DD Kelly, M Brutus, CB Greenman and M Glusman. Reversal of stress-induced analgesia by apomorphine, but not by amphetamine. Pharmacol. Biochem. Behav. 13: 171-175, 1980.

Bodnar, RJ, DD Kelly, M Brutus and M Glusman. Stress-induced analgesia: neural and hormonal determinants. Neurosci. Biobehav. Rev. 4: 87-100, 1980.

Bodnar, RJ, GM Abrams, EA Zimmerman, DT Krieger, G Nicholson and JS Kizer. Neonatal monosodium glutamate: effects upon analgesic responsivity and immunocytochemical ACTH/beta-lipotropin. Neuroendocrinology 30: 280-284, 1980.

Bodnar, RJ, DD Kelly, A Mansour and M Glusman. Differential effects of hypophysectomy upon analgesia induced by two glucoprivic stressors and morphine. Pharmacol. Biochem. Behav. 11: 303-308, 1979.

Bodnar, RJ, DD Kelly and M Glusman. 2-deoxy-D-glucose analgesia: influences of opiate and non-opiate factors. Pharmacol. Biochem. Behav. 11: 297-301, 1979.

Spiaggia, A, RJ Bodnar, DD Kelly and M Glusman. Opiate and non-opiate mechanisms of stress-induced analgesia: cross-tolerance studies between stressors. Pharmacol. Biochem. Behav. 10: 761-765, 1979.

Bodnar, RJ, M Glusman, M Brutus, A Spiaggia and DD Kelly. Analgesia induced by cold-water stress: attenuation following hypophysectomy. Physiol. Behav. 23: 53-62, 1979.

Bodnar, RJ, DD Kelly, M Brutus and M Glusman. Chronic 2-deoxy-D-glucose treatment: adapta-tion of its analgesic, but not hyperphagic properties. Pharmacol. Biochem. Behav. 9: 763-768, 1978.

Bodnar, RJ, DD Kelly, M Brutus, A Mansour and M Glusman. 2-deoxy-D-glucose-induced decrements in operant and reflex pain thresholds. Pharmacol. Biochem. Behav. 9: 543-549, 1978.

Bodnar, RJ, DD Kelly, A Spiaggia and M Glusman. Biphasic alterations of nociceptive thresholds induced by food deprivation. Physiol. Psychol. 6: 391-395, 1978.

Bodnar, RJ, DD Kelly, A Spiaggia, C Ehrenberg and M Glusman. Dose-dependent reductions by naloxone of analgesia induced by cold-water swims. Pharmacol. Biochem. Behav. 8: 667-672, 1978.

Bodnar, RJ, DD Kelly, SS Steiner and M Glusman. Stress-produced analgesia and morphine-produced analgesia: lack of cross-tolerance. Pharmacol. Biochem. Behav. 8: 661-666, 1978.

Bodnar, RJ, DD Kelly, A Spiaggia, C Pavlides and M Glusman. Stress-induced analgesia: effect of naloxone following cold-water swims. Bull. Psychonom. Soc. 12: 125-128, 1978.

Bodnar, RJ, DD Kelly, A Spiaggia and M Glusman. Stress-induced analgesia: adaptation following chronic cold-water swims. Bull. Psychonom. Soc. 11: 337-340, 1978.

Bodnar, RJ, DD Kelly and M Glusman. Stress-induced analgesia: time course of pain reflex alterations following cold-water swims. Bull. Psychonom. Soc. 11: 333-336, 1978.